原著論文

2023

  1. Miura Y, Tsumoto H, Masui Y, Inagaki H, Ogawa M, Ideno Y, Kawakami K, Umezawa K, Kabayama M, Akagi Y, Akasaka H, Yamamoto K, Rakugi H, Ishizaki T, Arai Y, Ikebe K, Kamide K, Gondo Y, Endo T. A characteristic N-glycopeptide signature associated with diabetic cognitive impairment identified in a longitudinal cohort study. Biochim. Biophys. Acta. Gen. Subj. 2023,  1867, 130316.
  2. Mori S, Suzuki S, Konishi T, Kawaguchi N, Kishi M, Kuwabara S, Ishizuchi K, Zhou H, Shibasaki F, Tsumoto H, Omura T, Miura Y, Mori S, Higashihara M, Murayama S, Shigemoto K. Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis. Exp. Neurol. 2023, 361, 114300.

2022

  1. Ueda, Y., Miura, Y., Tomishige, N., Sugimoto, N., Murase, M., Kawamura, G., Sasaki, N., Ishiwata, T., Ozawa., T. Cancer drug resistance via the protein synthesis pathway is revealed through optogenetic PI3K hyperactivation. Cell Chem. Biol. 2022 in press　リンク
  2. Mizutani, K., Kawakami, K., Fujita, Y., Kato, T., Takai, M., Kato, D., Iinuma, K., Koie, T., Ito, M. Gene therapy of prostate cancer using liposomes containing perforin expression vector driven by the promoter of prostate-specific antigen gene. Sci. Rep. 2022, 12, 1442.　リンク

2021

  1. Kawakami, K., Fujita, Y., Kato, T., Horie, K., Koie, T., Umezawa, K., Tsumoto, H., Miura, Y., Katagiri, Y., Miyazaki, T., Ohsawa, I., Mizutani, K., Ito, M. Diagnostic potential of serum extracellular vesicles expressing prostate-specific membrane antigen in urologic malignancies, Sci Rep. 2021, 11, 15000.　リンク
  2. Imae, R., Manya, H., Tsumoto, H., Miura, Y., Endo, T. PCYT2 synthesizes CDP-glycerol in mammals and reduced PCYT2 enhances the expression of functionally glycosylated α-dystroglycan. J. Biochem. 2021, 170,183-194.　リンク
  3. Sato, M., Tsumoto, H., Toba, A., Soejima, Y., Arai, T., Harada, K., Miura, Y., Sawabe, M. Proteome Analysis Demonstrates Involvement of Endoplasmic Reticulum Stress Response in Human Myocardium with Subclinical Left Ventricular Diastolic Dysfunction. Geriatrics & Gerontology International, 2021, 21, 577-583.　リンク
  4. Hishida, S., Kawakami, K., Fujita, Y., Kato, T., Takai, M., Iinuma, K., Nakane K., Tsuchiya, T., Koie, T., Miura, Y., Ito, M., Mizutani, K. Proteomic analysis of extracellular vesicles identified PI3K pathway as a potential therapeutic target for cabazitaxel-resistant prostate cancer, Prostate, 2021, 81, 592-602.　リンク
  5. Muramatsu-Maekawa, Y., Kawakami, K., Fujita, Y., Takai, M., Kato, D., Nakane, K., Kato, T., Tsuchiya, T., Koie, T., Miura, Y., Ito, M., Mizutani, K. Profiling of serum extracellular vesicles reveals miRNA-4525 as a potential biomarker for advanced renal cell carcinoma, Cancer Genomics & Proteomics, 2021, 18, 253-259.　リンク
  6. Iinuma, K., Kawakami, K., Mizutani, K., Fujita, Y., Yamaguchi, T., Ito, M., Kumano, T., Matsuo, M., Nakano, M., Koie, T., Ito, M., Kato, T. miRNA-93 in Serum Extracellular Vesicles Before and After Low Dose Rate Prostate Brachytherapy, Anticancer Res., 2021, 41, 2411-2418.　リンク
  7. Takai, M., Kawakami, K., Fujita, Y., Kato, T., Kato, D., Iinuma, K., Koie, T., Ito, M., Mizutani, K. Kartogenin Inhibits Prostate Cancer Cell Growth Through Smad2 Activation and Decreases Androgen Receptor Nuclear Localization. Anticancer Res. 2021, 41, 4753-4759.　リンク
  8. Takahashi, H., Kamiya, M., Kawatani, M., Umezawa, K., Ukita, Y., Niwa, S., Oda, T., Urano, Y. Neural and behavioral control in Caenorhabditis elegans by a yellow-light-activatable caged compound, Proc. Natl. Acad. Sci. USA. 2021, 118, e2009634118.　リンク

2020

  1. Kato, T., Mizutani, K., Kawakami, K., Fujita, Y., Ehara, H., Ito, M. CD44v8-10 mRNA contained in serum exosomes as a diagnostic marker for docetaxel resistance in prostate cancer patients. Heliyon.  2020, 6, e04138.　リンク
  2. Horie, K., Kawakami, K., Fujita, Y., Matsuda, Y., Arai, T., Suzui, N., Miyazaki, T., Koie, T., Mizutani, K., Ito M. Serum Exosomal Gamma-Glutamyltransferase Activity Increased in Patients with Renal Cell Carcinoma with Advanced Clinicopathological Features. Oncology. 2020, 98, 734-742.　リンク
  3. Morozumi, A., Kamiya, M., Uno, S., Umezawa, K., Kojima, R., Yoshihara, T., Tobita, S., Urano, Y. Spontaneously blinking fluorophores based on nucleophilic addition/dissociation of intracellular glutathione for live-cell super-resolution imaging, J. Am. Chem. Soc. 2020, 142, 9625-9633.　リンク
  4. Ozawa, K., Tsumoto, H., Miura, Y., Yamaguchi, J., Iguchi-Ariga, S.M.M., Sakuma, T., Yamamoto, T., Uchiyama, Y. DJ-1 is indispensable for S-nitrosylation of parkin, which maintains the function of mitochondria, Sci. Rep. 2020, 10, 4377.　リンク
  5. Kuwabara, N., Imae, R., Manya, H., Tanaka, T., Mizuno, M., Tsumoto, H., Kanagawa, M., Kobayashi, K., Toda, T., Senda, T., Endo, T., Kato, R. Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy. Nat. Commun. 2020, 11, 303.　リンク

2019

  1. Mizutani, K., Kawakami, K., Horie, K., Fujita, Y., Kameyama, K., Kato, T., Nakane, K., Tsuchiya, T., Yasuda, M., Masunaga, K., Kasuya, Y., Masuda, Y., Deguchi, T., Koie, T., Ito, M. Urinary exosome as a potential biomarker for urinary tract infection. Cell Microbiol. 2019, 21, e13020.
  2. Edo, N., Kawakami, K., Fujita, Y., Morita, K., Uno, K., Tsukamoto, K., Onose, H., Ishikawa, T., Ito, M. Exosomes Expressing Thyrotropin Receptor Attenuate Autoantibody-Mediated Stimulation of Cyclic Adenosine Monophosphate Production. Thyroid. 2019, 29, 1012-1017.
  3. Miura, Y., Tsumoto, H., Iwamoto, M., Yamaguchi, Y., Ko, P., Soejima, Y., Yoshida, S., Toda, T., Arai, T., Hamamatsu, A., Endo, T., Sawabe, M. Age-associated proteomic alterations in human aortic media. Geriatr. Gerontol. Int. 2019, 19, 1054-1062.
  4. Enomoto, A., Fukasawa, T., Tsumoto, H., Karube, M., Nakagawa, K., Yoshizaki, A., Sato, S., Miura, Y., Miyagawa, K. Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation. Sci. Rep. 2019, 9, 16010.
  5. Hanamatsu, H., Nishikaze, T., Tsumoto, H., Ogawa, K., Kobayashi, T., Yokota, I., Morikawa, K., Suda, G., Sho, T., Nakai, M., Miura, N., Higashino, K., Sekiya, S., Iwamoto, S., Miura,Y., Furukawa, J., Tanaka, K., Sakamoto, N. Comparative glycomic analysis of sialyl linkage isomers by sialic acid linkage-specific alkylamidation in combination with stable isotope labeling of α2,3-linked sialic acid residues. Anal. Chem. 2019, 91, 13343-13348.
  6. Akimoto, Y., Yan, K., Miura, Y., Tsumoto, H., Toda, T., Fukutomi, T., Sugahara, D., Kudo, A., Arai, T., Chiba, Y., Kaname, S., Hart, G. W., Endo, T., Kawakami, H. O-GlcNAcylation and Phosphorylation of β-Actin Serine199 in Diabetic Nephropathy. Am. J. Physiol. Renal Physiol. 2019, 317, F1359-1374.
  7. Miura, Y., Hayakawa, A., Kikuchi, S., Tsumoto, H., Umezawa, K., Chiba, Y., Soejima, Y., Sawabe, M., Fukui, K., Akimoto, Y., Endo, T. Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats. Arch. Biochem. Biophys. 2019, 678, 108167.
  8. Kobayashi, M., Hoshino, S., Abe, T., Okita, N., Tagawa, R., Nagai, W., Konno, R., Suzuki, Y., Furuya, K., Ishikawa, N., Okado, H., Oku, M., Iwamoto, M., Miura, Y., Sudo, Y., Higami, Y. Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes. Biochem. Biophys. Res. Commun., 2019, 508, 117-122.
  9. Fukui, K., Okihiro, S., Ohfuchi, Y., Hashimoto, M., Kato, Y., Yoshida, N., Mochizuki, K., Tsumoto, H., Miura, Y. Proteomic study on neurite responses to oxidative stress: search for differentially expressed proteins in isolated neurites of N1E-115 cells. J. Clin. Biochem. Nutr., 2019, 64, 36-44.
  10. Mellini, P.; Itoh, Y.; Elboray, E.E.; Tsumoto, H.; Li, Y.; Suzuki, M.; Takahashi, Y.; Tojo, T.; Kurohara, T.; Miyake, Y.; Miura, Y.; Kitao, Y.; Kotoku, M.; Iida, T.; Suzuki, T. Identification of diketopiperazine-containing 2-anilinobenzamides as potent surtuin 2 (SIRT2)-selective inhibitors targeting the “Selectivity pocket”, substrate-binding site, and NAD+-binding site. J. Med. Chem. 2019, 62, 5844-5862.
  11. Mizutani, K., Horie, K., Kato, T., Nakane, K., Kawakami, K., Fujita, Y., Ito, M. Serum PD-1 levels measured by ELISA using Nivolumab increased in advanced RCC patients: novel approach to develop companion diagnostics for antibody therapy. J. Cancer Res. Clin. Oncol. 2019,145, 1661-1663.

2018

  1. Nishihara, R., Kobayashi, K., Imae, R., Tsumoto, H., Manya, H., Mizuno, M., Kanagawa, M., Endo, T., Toda, T. Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5. Biochem. Biophys. Res. Commun., 2018, 497, 1025-1030.
  2. Goto, Y., Ogawa, Y., Tsumoto, H., Miura, Y., Nakamura, T.J., Ogawa, K., Akimoto, Y., Kawakami, H., Endo, T., Yanoshita, R., Tsujimoto, M. Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation. Biochim. Biophys. Acta., 2018, 1865, 874-888.
  3. Miura, Y., Hashii, N., Ohta, Y., Itakura, Y., Tsumoto, H., Suzuki, J., Takakura, D., Abe, Y., Arai, Y., Toyoda, M., Kawasaki, N., Hirose, N., Endo, T. Characteristic glycopeptides associated with extreme human longevity identified through plasma glycoproteomics. Biochim. Biophys. Acta., 2018, 1862, 1462-1471.
  4. Imae, R., Manya, H., Tsumoto, H., Osumi, K., Tanaka, T., Mizuno, M., Kanagawa, M., Kobayashi, K., Toda, T., Endo, T. CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan. J. Biol. Chem., 2018, 293, 12186-12198.
  5. Umezawa, K., Kamiya, M., Urano, Y. A reversible fluorescent probe for real-time live-cell imaging and quantification of endogenous hydropolysulfides. Angew. Chem. Int. Ed., 2018, 57, 9346–9350.
  6. Takahashi, K., Miura, Y., Ohsawa, I., Shirasawa, T., Takahashi, M. In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization. Sci. Rep., 2018, 8, 15585.

2017

  1. Kobayashi, M., Takeda, K., Narita, T., Nagai, K., Okita, N., Sudo, Y., Miura, Y., Tsumoto, H., Nakagawa, Y., Shimano, H., Higami, Y. Mitochondrial Intermediate Peptidase is a Novel Regulator of Sirtuin-3 Activation by Caloric Restriction. FEBS Letters, 2017, 591, 4067–4073.
  2. Tsumoto, H., Akimoto, Y., Endo, T., Miura, Y. Quantitative analysis of O-GlcNAcylation in combination with isobaric tag labeling and chemoenzymatic enrichment. Bioorg. Med. Chem. Lett., 2017, 27, 5022–5026.
  3. Mellini, P., Itoh, Y., Tsumoto, H., Li, Y., Suzuki, M., Tokuda, N., Kakizawa, T., Miura, M., Takeuchi, J., Lahtela-Kakkonene, M., Suzuki, T. Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD+-binding site. Chem. Sci., 2017, 8, 6400–6408.
  4. Nishikaze, T., Tsumoto, H., Sekiya, S., Iwamoto, S., Miura, Y., Tanaka, K. Differentiation of Sialyl Linkage Isomers by One-Pot Sialic Acid Derivatization for Mass Spectrometry-Based Glycan Profiling. Anal. Chem. 2017, 89, 2353–2360.
  5. Akasaka-Manya, K., Kawamura, M., Tsumoto, H., Saitoh, Y., Kitazume, S., Hatsuda, H., Miura, Y., Hisanaga, S., Murayama, S., Hashimoto, Y., Manya, H., Endo, T. Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production. J. Biochem. 2017, 161, 99–111.
  6. Murakami, M., Kameda, K., Tsumoto, H., Tsuda, T., Masuda, K., Utsunomiya, R., Mori, H., Miura, Y., Sayama, K. TLN-58, newly discovered hCAP18 processing form, found in the lesion vesicle of palmoplantar pustulosis in the skin. J. Invest. Dermatol. 2017, 137, 322–331.

2016

  1. Itoh, Y., Aihara, K., Mellini, P., Tojo, T., Ota, Y., Tsumoto, H., Solomon, V.R., Zhan, P., Suzuki, M., Ogasawara, D., Shigenaga, A., Inokuma, T., Nakagawa, H., Miyata, N., Mizukami, T., Otaka, A., Suzuki, T. Identification of SNAIL1 peptide-based irreversible lysine-specific demethylase 1-selective inactivators. J. Med. Chem. 2016, 59, 1531–1544.

2015

  1. Miura, Y., Hashii, N., Tsumoto, H., Takakura, D., Ohta, Y., Abe, Y., Arai, Y., Kawasaki, N., Hirose, N., Endo, T., on behalf of SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians). Change in N-glycosylation of plasma proteins in Japanese semisupercentenarians. PLos One, 2015, 10, e0142645.
  2. Tsumoto, H., Ogasawara, D., Hashii, N., Suzuki, T., Akimoto, Y., Endo, T., Miura, Y. Enrichment of O-GlcNAc-modified peptides using a novel thiol-alkyne and thiol-disulfide exchange. Bioorg. Med. Chem. Lett. 2015, 25, 2645–2649.
  3. Xin, X.; Akasaka-Manya, K.; Manya, H.; Furukawa, J.; Kuwahara, N.; Okada, K.; Tsumoto, H.; Higashi, N.; Kato, R.; Shinohara, Y.; Irimura, T.; Endo, T. POMGNT1 Is Glycosylated by Mucin-Type O-Glycans. Biol. Pharm. Bull. 2015, 38, 1389–1394.
  4. Kawakami, K., Fujita, Y., Kato, T., Mizutani, K., Kameyama,K., Tsumoto, H., Miura, Y., Deguchi, T., Ito, M.  Integrin β4 and vinculin contained in exosomes are potential markers for progression of prostate cancer associated with taxane-resistance. Int. J. Oncol. 2015, 47, 384–390.
  5. Moriyama, T., Ito, A., Omote, S., Miura, Y., Tsumoto, H.: Heat-Resistant Characteristics of Major Royal Jelly Protein 1 (MRJP1) Oligomer. PLos One, 2015, 10, e0119169.
  6. Miura, Y., Iwamoto, M., Tsumoto, H., Endo, T., Toda, T. Antioxidant effects of carnitine supplementation using fully automated two-dimensional chip gel electrophoresis. Electrophoresis Lett. 2015, 59, 109–111.
  7. Kakizawa, T., Ota, Y., Itoh, Y., Tsumoto, H., Suzuki, T. Histone H3 peptide based LSD1-selective inhibitors. Bioorg. Med. Chem. Lett. 2015, 25, 1925–1928.
  8. Khan, M.N.A., Tsumoto, H., Itoh, Y., Ota, Y., Suzuki, M., Ogasawara, D., Nakagawa, H., Mizukami, T., Miyata N., Suzuki, T. Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1. Med. Chem. Commun. 2015, 6, 407–412.

2014

  1. Iwamoto, M., Miura, Y., Tsumoto, H., Tanaka, Y., Morisawa, H., Endo, T., Toda, T. Antioxidant effects of carnitine supplementation on 14-3-3 protein isoforms in the aged rat hippocampus detected using fully automated two-dimensional chip gel electrophoresis. Free Radic. Res., 2014, 48, 1409–1416.
  2. Miura, Y., Sato, T., Sakurai, Y., Sakai, R., Hiraoka, W., Endo, T. Hyper O-GlcNAcylation inhibits HSP 70-induction caused by sodium arsenite in HeLa cells. Biol. Pharm. Bull. 2014, 37, 1308–1314.

2013

  1. Miura, Y., & Endo, T. Challenge to successful aging -Proteomics on centenarians as a powerful tool for gerontology, Biomedical Gerotology, 2013, 37, 23–27.
  2. Ogasawara, D., Itoh, Y., Tsumoto, H., Kakizawa, T., Mino, K., Fukuhara, K., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T., Miyata, N., Suzuki, T. Lysine-Specific Demethylase 1-Selective Inactivators: Protein-Targeted Drug Delivery Mechanism. Angew. Chem. Int. Ed. 2013, 52, 8620–8624.
  3. Ozawa, K., Komatsubara, A.T., Nishimura, Y., Sawada, T., Kawafune, H., Tsumoto, H., Tsuji, Y., Zhao, J., Kyotani, Y., Tanaka, T., Takahashi, R., Yoshizumi, M. S-nitrosylation regulates mitochondrial quality control via activation of parkin. Sci. Rep. 2013, 3, 1–10.