{"id":8,"date":"2016-11-14T15:46:32","date_gmt":"2016-11-14T06:46:32","guid":{"rendered":"http:\/\/tmig-proteome.org\/?page_id=8"},"modified":"2026-04-08T11:02:47","modified_gmt":"2026-04-08T02:02:47","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/tmig-proteome.org\/?page_id=8","title":{"rendered":"\u539f\u8457\u8ad6\u6587"},"content":{"rendered":"

2025<\/strong><\/p>\n

    \n
  1. Uchiyama, J., Shimizu, Y., Unoki, T., Kasamatsu, S., Ida, T., Ihara, H., Kim, Y. G., Hase, K., Miura, Y.<\/u>, Maehama, T., Kusano, M., Umezawa, K.<\/u>, Akiyama, M.\uff1aFormation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides. Redox Biology<\/em>, 92, 104123, (2026) [IF11.9, 2024]<\/li>\n
  2. Shichi, Y.*, Tsumoto, H.*<\/u>, Fujiwara, M., Nonaka, K., Hasegawa, Y., Shinji, S., Rokutan, H., Takahashi, K., Arai, T., Miura, Y.<\/u>, Ishiwata, T.: Proteomic and immunocytochemical analyses of squamous components in two- and three-dimensional-cultured pancreatic ductal adenocarcinoma cell lines, Oncology Letters<\/em>, 31, 185, (2026) [IF2.2, 2024] *These authors contributed equally to this work.<\/em><\/li>\n
  3. Shiiba, I., Ishikawa, Y., Oshio, H., Ito, N., Yamaguchi, F., Nagashima, S., Ando, H., Umezawa, K.<\/u>, Miura, Y.<\/u>, Araiso, Y., Nakamura, K., Hirabayashi, Y., Inatome, R., & Yanagi, S.: MFN2-STIM1-mediated mitochondria-melanosome contact: A key to melanosome maturation, Commun. <\/em>accepted, <\/em>(2026) [IF15.7, 2024]<\/li>\n
  4. Ikeda-Imafuku, M., Sakai, M., Umezawa, K.<\/u>, Nakagawa, H., Maruyama, T., Otagiri, M., AkaikeT., Sawa, T., Xian, M., Miura, Y.<\/u>, Ishida, T., Ishima, Y.: Unique response of polysulfide in serum albumin against oxidative stress, Rep.<\/em> 15, 42689 (2025) [IF3.9, 2024]<\/li>\n
  5. Akimoto, Y., Miura, Y.<\/u>, Kudo, A., Fukutomi, T., Arai, T., Chiba, Y., Kaname, S., Yan, K., Endo, T., Hart, G.W.: The O<\/em>-GlcNAcylation of \u03b2-actin Ser199 controls nuclear speckle localization and is dysregulated in diabetes, Histochem. Cell Biol.<\/em> 163, 106 (2025) [IF2.1, 2024]<\/li>\n
  6. Mukherjee, A., Yamashita, Y., Maeda, R., Akiyama, T., Endo, K., Takada, Y., Tsumoto, H.<\/u>, Moriyama, Y., Ito, A., Shirai, F., Tachibana, M., Itoh, Y., Suzuki, T. A Novel PROTAC G9a\/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation. Med. Chem.,<\/em> 68<\/em>, 18258-18271, (2025) Supplementary Cover <\/em><\/strong>[IF6.8, 2024]<\/li>\n
  7. Takikawa, K., Namiki, S., Umezawa, K.<\/u>, Asanuma, D., Hirose, K., Nishimune H.: Development of a Hybrid-Type Fluorescent GABA Sensor through Structure-Guided Efficient Screening. ACS Sensors<\/em> 10, 7302-7312, (2025) [IF1, 2024]<\/li>\n
  8. Sasaki,N., Kawakami, K.<\/u>, Itakura, Y., Fujita, T., Miyagawa, S., Ishigami, T., Kubo, H., Miura, Y.<\/u>, Chiba, Y.: Characterization of extracellular vesicles derived from cortical bone stem cells compared with Mesenchymal stem cells, Cell. Biochem<\/em>. 480, 5861-5876, (2025) [IF3.7, 2024]<\/li>\n
  9. Kawakami, K.<\/u>, Edo, N., Morita, K., Ishikawa, T., Onose, H., Fukumori, T., Tsumoto, H.<\/u>, Umezawa, K.<\/u>, Ito, M., Miura, Y.<\/u>: Proteomic analysis reveals elevated RAB21 in serum-derived extracellular vesicles from follicular thyroid carcinoma patients, Oncology Letters<\/em>, 30, 444, (2025) [IF2.2, 2024]<\/li>\n
  10. Mori, S., Zhou, H., Omura, T., Tsumoto, <\/u>, Miura, Y.<\/u>, Shigemoto, K.: Muscle-specific kinase levels in blood are an early diagnostic biomarker for SOD1-93A mouse model of ALS, <\/strong>Front. Neurol.<\/em>, 16, 1556120, (2025) [IF2.8, 2024]<\/li>\n
  11. Yoshida, Y, Ishizaki, T, Hirata,T, Masui, Y, Inagaki, H, Miura, Y<\/u>, Ogawa, M, Ito, K, Arai, Y, Kamide, K, Ikebe, K, Gondo, Y.: Impact of polypharmacy on self-rated health in community-dwelling older adults: A 3-year SONIC study, Am. Med. Dir. Assoc.<\/em> 26, 105621, (2025) [IF4.2 2024]<\/li>\n<\/ol>\n

    2024<\/strong><\/p>\n

      \n
    1. Shiiba, I., Ito, N., Oshio, H., Ishikawa, Y., Nagao, T., Shimura, H., Oh, K. W., Takasaki, E., Yamaguchi, F., Konagaya, R., Kadowaki, H., Nishitoh, H., Tanzawa, T., Nagashima, S., Sugiura, A., Fujikawa, Y., Umezawa, K<\/u>., Tamura, Y., Lee, B., Hirabayashi, Y., Okazaki, Y., Sawa, T., Inatome, R., Yanagi, S.: ER-mitochondria contacts mediate lipid radical transfer via RMDN3\/PTPIP51 phosphorylation to reduce mitochondrial oxidative stress. Nature Communications, 16, 1508, <\/em>(2025)\u00a0\uff08\u67fb\u8aad\u3042\u308a\uff09[IF14.7; 2023]<\/li>\n
    2. Nishimura, A., Ogata, S., Tang, X., Hengphasatporn, K., Umezawa, K.<\/u>, Sanbo, M., Hirabayashi, M., Kato, Y., Ibuki, Y., Kumagai, Y., Kobayashi, K., Kanda, Y., Urano, Y., Shigeta, Y., Akaike, T., Nishida, M.: Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice. Nature Communications, 16, 276, (2025) \uff08\u67fb\u8aad\u3042\u308a\uff09[IF14.7; 2023]<\/li>\n
    3. Nishimura, A., Tanaka, T., Shimoda, K., Ida, T., Sasaki, S., Umezawa, K<\/u>., Imamura, H., Urano, Y., Ichinose, F., Kaneko, T., Akaike, T., Nishida, M.: Non-thermal atmospheric pressure plasma-irradiated cysteine protects\u00a0cardiac ischemia\/reperfusion injury by preserving supersulfides, Redox Biology, 79,\u3000103445,\u3000(2024)\uff08\u67fb\u8aad\u3042\u308a\uff09[IF10.7; 2023]<\/li>\n
    4. Ebina, M., Miura, Y.<\/u>, Sakane, F.: Ubiquitin-specific peptidase 11 selectively interacts with and deubiquitination-dependently stabilizes diacylglycerol kinase \uf064 to maintain cellular glucose uptake, Biochim. Biophys. Acta, -Molecular Cell Research, 1872, 119883, (2024)\uff08\u67fb\u8aad\u3042\u308a\uff09[IF4.6; 2023]<\/li>\n
    5. Wu, T., Sun, Y., Wang, D., Isaji, T., Fukuda, T., Suzuki, C., Hanamatsu, H., Nishikaze, T., Tsumoto, H.<\/u>, Miura,\u00a0Y.<\/u>, Furukawa,\u00a0J., Gu, J.: The acetylglucosaminyltransferase GnT-\u2162\u00a0regulates\u00a0erythroid differentiation through ERK\/MAPK signaling, J Biol Chem, 300, 108010, (2024)\uff08\u67fb\u8aad\u3042\u308a\uff09[IF4.0; 2023]<\/li>\n
    6. Kato, T., Sugihara, E., Hata, Y., Kawakami, K<\/u>., Fujita, Y., Mizutani, K., Ando, T., Sakai, Y., Sakurai, K., Toyota, S., Ehara, H., Ito, M., Ito, H.: Diagnostic potential of SDHB mRNA contained in serum extracellular vesicles among patients with prostate cancer.\u00a0The Prostate. 84, 1515-1524, (2024) \uff08\u67fb\u8aad\u3042\u308a\uff09[IF2.6; 2023]<\/li>\n
    7. Kondo, M., Nakamura, Y., Kato, Y., Nishimura, A., Fukata, M., Moriyama, S., Ito, T., Umezawa, K.<\/u>, Urano, Y., Akaike, T., Akashi, K., Kanda, Y., Nishida, M.: Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes, J. Pharmacol. Sci. 156, 69-76, (2024) \uff08\u67fb\u8aad\u3042\u308a\uff09[IF3.0; 2023]<\/li>\n
    8. Zhou, L., Nishimura, A., Umezawa, K.<\/u>, Kato, Y., Mi, X., Ito, T., Urano, Y., Akaike, T., Nishida, M.: Supersulfide catabolism participates in maladaptive remodeling of cardiac cells. J. Pharmacol. Sci. 155, 121-130, (2024) \uff08\u67fb\u8aad\u3042\u308a\uff09[IF3.0; 2023]<\/li>\n
    9. Yoshida, Y., Ishizaki, T., Masui, M., Miura, Y.<\/u>, Matsumoto, K., Nakagawa, T., Inagaki, H., Ito, K., Arai, Y., Kabayama, M., Kamide, K., Rakugi, H., Ikebe, K., Gondo, Y.: Effects of multimorbidity and polypharmacy on physical function in community-dwelling older adults: a 3-year follow-up analysis of the SONIC study, Arch. Gerontol.Geriatr. 126, 105521, (2024) \uff08\u67fb\u8aad\u3042\u308a\uff09[IF2023: 3.5]<\/li>\n
    10. Imae, R., Manya, H., Tsumoto, H.<\/u>, Umezawa, K.<\/u>, Miura, Y.<\/u>, and Endo, T.: Changes in the amount of nucleotide sugars in aged mouse tissues, Glycobiology, 34, cwae032, (2024) \uff08\u67fb\u8aad\u3042\u308a\uff09[IF3.4; 2023]<\/li>\n
    11. Zhang, Z., Aoki, H., Umezawa, K.<\/u>, Kranrod, J., Miyazaki, N., Oshima,T., Hirao, T., Miura, Y.<\/u>, Ito, K., Aoki, S: Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells, Cell Death Discov., 10(1), 166, (2024) \uff08\u67fb\u8aad\u3042\u308a\uff09[IF6.1; 2023]<\/li>\n
    12. Kato, Y., Byeon, J., Noto, A. Kashiwaya, S., Aoki, Y., Watanabe, N., Tsumoto, H.<\/u>, Miura, Y.<\/u>, Fukui, K.: Tocotrienols prevent the decline of learning ability in high-fat high-sucrose diet-fed C57BL\/6 mice, Int. J. Mol. Sci., 25(6), 3561 (2024)\uff08\u67fb\u8aad\u3042\u308a\uff09[IF4.9; 2023]<\/li>\n
    13. Ogawa, Y., Miura, Y.<\/u>, Ikemoto, M., Ohnishi, A., Goto, Y., Aoki, K., Motokurumada, Y., Akimoto, Y., Endo, T., Tsujimoto, M., Yanoshita, R.: Distinguishing two distinct types of salivary extracellular vesicles: A potential tool for 5 understanding their pathophysiological roles, Front. Mol. Biosci. 11, 1278955 (2024)\uff08\u67fb\u8aad\u3042\u308a\uff09[IF3.9; 2023]<\/li>\n<\/ol>\n

      2023<\/strong><\/p>\n

        \n
      1. \n
        Miura Y, Tsumoto H, Masui Y, Inagaki H, Ogawa M, Ideno Y, Kawakami K, Umezawa K, Kabayama M, Akagi Y, Akasaka H, Yamamoto K, Rakugi H, Ishizaki T, Arai Y, Ikebe K, Kamide K, Gondo Y, Endo T.<\/span> A characteristic N<\/em>-glycopeptide signature associated with diabetic cognitive impairment identified in a longitudinal cohort study. Biochim. Biophys. Acta. Gen. Subj.<\/em> 2023<\/strong>,\u00a0 1867, 130316.
        \n<\/span><\/div>\n<\/li>\n
      2. Mori S, Suzuki S, Konishi T, Kawaguchi N, Kishi M, Kuwabara S, Ishizuchi K, Zhou H, Shibasaki F, Tsumoto H, Omura T, Miura Y, Mori S, Higashihara M, Murayama S, Shigemoto K.<\/span> Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis. Exp. Neurol.<\/em> 2023<\/strong>, 361, 114300.<\/span><\/li>\n<\/ol>\n

        2022<\/strong><\/p>\n

          \n
        1. Ueda, Y., Miura, Y.<\/u>, Tomishige, N., Sugimoto, N., Murase, M., Kawamura, G., Sasaki, N., Ishiwata, T., Ozawa., T. Cancer drug resistance via the protein synthesis pathway is revealed through optogenetic PI3K hyperactivation. Cell Chem. Biol.<\/em> 2022<\/strong> in press\u3000\u30ea\u30f3\u30af<\/a><\/em><\/li>\n
        2. Mizutani, K., Kawakami, K.<\/u>, Fujita, Y., Kato, T., Takai, M., Kato, D., Iinuma, K., Koie, T., Ito, M. Gene therapy of prostate cancer using liposomes containing perforin expression vector driven by the promoter of prostate-specific antigen gene. Sci. Rep.<\/em> 2022<\/strong>, 12<\/em>, 1442.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n<\/ol>\n

          2021<\/strong><\/p>\n

            \n
          1. Kawakami, K., Fujita, Y., Kato, T., Horie, K., Koie, T., Umezawa, K., Tsumoto, H., Miura, Y., Katagiri, Y., Miyazaki, T., Ohsawa, I., Mizutani, K., Ito, M. Diagnostic potential of serum extracellular vesicles expressing prostate-specific membrane antigen in urologic malignancies, Sci Rep. 2021<\/strong>, 11, 15000.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
          2. Imae, R., Manya, H., Tsumoto, H.<\/u>, Miura, Y.<\/u>, Endo, T. PCYT2 synthesizes CDP-glycerol in mammals and reduced PCYT2 enhances the expression of functionally glycosylated \u03b1-dystroglycan. J. Biochem<\/em>. 2021<\/strong>, 170<\/em>,183-194.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
          3. Sato, M., Tsumoto, H., Toba, A., Soejima, Y., Arai, T., Harada, K., Miura, Y., Sawabe, M. Proteome Analysis Demonstrates Involvement of Endoplasmic Reticulum Stress Response in Human Myocardium with Subclinical Left Ventricular Diastolic Dysfunction. Geriatrics & Gerontology International, 2021<\/strong>, 21, 577-583.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
          4. Hishida, S., Kawakami, K., Fujita, Y., Kato, T., Takai, M., Iinuma, K., Nakane K., Tsuchiya, T., Koie, T., Miura, Y., Ito, M., Mizutani, K. Proteomic analysis of extracellular vesicles identified PI3K pathway as a potential therapeutic target for cabazitaxel-resistant prostate cancer, Prostate, 2021<\/strong>, 81, 592-602.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
          5. Muramatsu-Maekawa, Y., Kawakami, K., Fujita, Y., Takai, M., Kato, D., Nakane, K., Kato, T., Tsuchiya, T., Koie, T., Miura, Y., Ito, M., Mizutani, K. Profiling of serum extracellular vesicles reveals miRNA-4525 as a potential biomarker for advanced renal cell carcinoma, Cancer Genomics &\u00a0Proteomics<\/em>, 2021<\/strong>, 18, 253-259.\u3000<\/em>\u30ea\u30f3\u30af<\/a><\/li>\n
          6. Iinuma, K., Kawakami, K., Mizutani, K., Fujita, Y., Yamaguchi, T., Ito, M., Kumano, T., Matsuo, M., Nakano, M., Koie, T., Ito, M., Kato, T. miRNA-93 in Serum Extracellular Vesicles Before and After Low Dose Rate Prostate Brachytherapy, Anticancer Res., 2021<\/strong>, 41, 2411-2418.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
          7. Takai, M., Kawakami, K.<\/u>, Fujita, Y., Kato, T., Kato, D., Iinuma, K., Koie, T., Ito, M., Mizutani, K. Kartogenin Inhibits Prostate Cancer Cell Growth Through Smad2 Activation and Decreases Androgen Receptor Nuclear Localization. Anticancer Res.<\/em> 2021<\/strong>, 41<\/em>, 4753-4759.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
          8. Takahashi, H., Kamiya, M., Kawatani, M., Umezawa, K.<\/span>, Ukita, Y., Niwa, S., Oda, T., Urano, Y. Neural and behavioral control in Caenorhabditis elegans<\/em> by a yellow-light-activatable caged compound, Proc. Natl. Acad. Sci. USA.<\/em> 2021<\/strong>, 118, e2009634118.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n<\/ol>\n

            2020<\/strong><\/p>\n

              \n
            1. Kato, T., Mizutani, K., Kawakami, K., Fujita, Y., Ehara, H., Ito, M.\u00a0CD44v8-10 mRNA contained in serum exosomes as a diagnostic marker for docetaxel resistance in prostate cancer patients.\u00a0Heliyon<\/em>.\u00a0\u00a02020<\/strong>,\u00a06, e04138.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
            2. Horie, K., Kawakami, K., Fujita, Y., Matsuda, Y., Arai, T., Suzui, N., Miyazaki, T., Koie, T., Mizutani, K., Ito M. Serum Exosomal Gamma-Glutamyltransferase Activity Increased in Patients with Renal Cell Carcinoma with Advanced Clinicopathological Features. Oncology<\/em>. 2020<\/strong>, 98, 734-742.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
            3. Morozumi, A., Kamiya, M., Uno, S., Umezawa, K., Kojima, R., Yoshihara, T., Tobita, S., Urano, Y. Spontaneously blinking fluorophores based on nucleophilic addition\/dissociation of intracellular glutathione for live-cell super-resolution imaging, J. Am. Chem. Soc.<\/em> 2020<\/strong>, 142, 9625-9633.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
            4. Ozawa, K., Tsumoto, H.<\/u>, Miura, Y<\/u>., Yamaguchi, J., Iguchi-Ariga, S.M.M., Sakuma, T., Yamamoto, T., Uchiyama, Y. DJ-1 is indispensable for S-nitrosylation of parkin, which maintains the function of mitochondria, Sci. Rep.<\/em> 2020<\/strong>, 10<\/em>, 4377.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n
            5. Kuwabara, N., Imae, R., Manya, H., Tanaka, T., Mizuno, M., Tsumoto, H.<\/u>, Kanagawa, M., Kobayashi, K., Toda, T., Senda, T., Endo, T., Kato, R. Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy. Nat. Commun<\/em>. 2020<\/strong>, 11<\/em>, 303.\u3000\u30ea\u30f3\u30af<\/a><\/li>\n<\/ol>\n

              2019<\/strong><\/p>\n

                \n
              1. Mizutani, K., Kawakami, K.<\/u>, Horie, K., Fujita, Y., Kameyama, K., Kato, T., Nakane, K., Tsuchiya, T., Yasuda, M., Masunaga, K., Kasuya, Y., Masuda, Y., Deguchi, T., Koie, T., Ito, M. Urinary exosome as a potential biomarker for urinary tract infection. Cell Microbiol.<\/em> 2019<\/strong>, 21<\/em>, e13020.<\/li>\n
              2. Edo, N., Kawakami, K.<\/u>, Fujita, Y., Morita, K., Uno, K., Tsukamoto, K., Onose, H., Ishikawa, T., Ito, M. Exosomes Expressing Thyrotropin Receptor Attenuate Autoantibody-Mediated Stimulation of Cyclic Adenosine Monophosphate Production. Thyroid.<\/em> 2019<\/strong>, 29<\/em>, 1012-1017.<\/li>\n
              3. Miura, Y.<\/u>, Tsumoto, H.<\/u>, Iwamoto, M., Yamaguchi, Y., Ko, P., Soejima, Y., Yoshida, S., Toda, T., Arai, T., Hamamatsu, A., Endo, T., Sawabe, M. Age-associated proteomic alterations in human aortic media. Geriatr. Gerontol. Int.<\/em> 2019<\/strong>, 19<\/em>, 1054-1062.<\/li>\n
              4. Enomoto, A., Fukasawa, T., Tsumoto, H.<\/u>, Karube, M., Nakagawa, K., Yoshizaki, A., Sato, S., Miura, Y.<\/u>, Miyagawa, K. Prevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation. Sci. Rep.<\/em> 2019<\/strong>, 9<\/em>, 16010.<\/li>\n
              5. Hanamatsu, H., Nishikaze, T., Tsumoto, H.<\/u>, Ogawa, K., Kobayashi, T., Yokota, I., Morikawa, K., Suda, G., Sho, T., Nakai, M., Miura, N., Higashino, K., Sekiya, S., Iwamoto, S., Miura,Y<\/u>., Furukawa, J., Tanaka, K., Sakamoto, N. Comparative glycomic analysis of sialyl linkage isomers by sialic acid linkage-specific alkylamidation in combination with stable isotope labeling of \u03b12,3-linked sialic acid residues. Anal. Chem.<\/em> 2019<\/strong>, 91<\/em>, 13343-13348.<\/li>\n
              6. Akimoto, Y., Yan, K., Miura, Y.<\/u>, Tsumoto, H.<\/u>, Toda, T., Fukutomi, T., Sugahara, D., Kudo, A., Arai, T., Chiba, Y., Kaname, S., Hart, G. W., Endo, T., Kawakami, H. O-GlcNAcylation and Phosphorylation of \u03b2-Actin Serine199 in Diabetic Nephropathy. Am. J. Physiol. Renal Physiol.<\/em> 2019<\/strong>, 317<\/em>, F1359-1374.<\/li>\n
              7. Miura, Y.<\/u>, Hayakawa, A., Kikuchi, S., Tsumoto, H.<\/u>, Umezawa, K.<\/u>, Chiba, Y., Soejima, Y., Sawabe, M., Fukui, K., Akimoto, Y., Endo, T. Fumarate accumulation involved in renal diabetic fibrosis in Goto-Kakizaki rats. Arch. Biochem. Biophys.<\/em> 2019<\/strong>, 678, 108167.<\/li>\n
              8. Kobayashi, M., Hoshino, S., Abe, T., Okita, N., Tagawa, R., Nagai, W., Konno, R., Suzuki, Y., Furuya, K., Ishikawa, N., Okado, H., Oku, M., Iwamoto, M.<\/u>, Miura, Y.<\/u>, Sudo, Y., Higami, Y. Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes. Biochem. Biophys. Res. Commun.<\/em>, 2019<\/strong>, 508<\/em>, 117-122.<\/li>\n
              9. Fukui, K., Okihiro, S., Ohfuchi, Y., Hashimoto, M., Kato, Y., Yoshida, N., Mochizuki, K., Tsumoto, H.<\/u>, Miura, Y<\/u>. Proteomic study on neurite responses to oxidative stress: search for differentially expressed proteins in isolated neurites of N1E-115 cells. J. Clin. Biochem. Nutr.,<\/em> 2019<\/strong>, 64, 36-44.<\/li>\n
              10. Mellini, P.; Itoh, Y.; Elboray, E.E.; Tsumoto, H.<\/u>; Li, Y.; Suzuki, M.; Takahashi, Y.; Tojo, T.; Kurohara, T.; Miyake, Y.; Miura, Y.<\/u>; Kitao, Y.; Kotoku, M.; Iida, T.; Suzuki, T. Identification of diketopiperazine-containing 2-anilinobenzamides as potent surtuin 2 (SIRT2)-selective inhibitors targeting the “Selectivity pocket”, substrate-binding site, and NAD+-binding site. J. Med. Chem.<\/em> 2019<\/strong>, 62<\/em>, 5844-5862.<\/li>\n
              11. Mizutani, K., Horie, K., Kato, T., Nakane, K., Kawakami, K.<\/u>, Fujita, Y., Ito, M. Serum PD-1 levels measured by ELISA using Nivolumab increased in advanced RCC patients: novel approach to develop companion diagnostics for antibody therapy. J. Cancer Res. Clin. Oncol.<\/em> 2019<\/strong>,145<\/em>, 1661-1663.<\/li>\n<\/ol>\n

                2018<\/strong><\/p>\n

                  \n
                1. Nishihara, R., Kobayashi, K., Imae, R., Tsumoto, H., Manya, H., Mizuno, M., Kanagawa, M., Endo, T., Toda, T. Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5. Biochem. Biophys. Res. Commun<\/span>.,<\/em> 2018<\/strong>, 497<\/em>, 1025-1030.<\/li>\n
                2. Goto, Y., Ogawa, Y., Tsumoto, H., Miura, Y., Nakamura, T.J., Ogawa, K., Akimoto, Y., Kawakami, H., Endo, T., Yanoshita, R., Tsujimoto, M. Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation. Biochim. Biophys. Acta<\/span>.,<\/em> 2018<\/strong>, 1865<\/em>, 874-888.<\/li>\n
                3. Miura, Y., Hashii, N., Ohta, Y., Itakura, Y., Tsumoto, H., Suzuki, J., Takakura, D., Abe, Y., Arai, Y., Toyoda, M., Kawasaki, N., Hirose, N., Endo, T. Characteristic glycopeptides associated with extreme human longevity identified through plasma glycoproteomics. Biochim. Biophys. Acta<\/span><\/em>., 2018<\/strong>, 1862<\/em>, 1462-1471.<\/li>\n
                4. Imae, R., Manya, H., Tsumoto, H., Osumi, K., Tanaka, T., Mizuno, M., Kanagawa, M., Kobayashi, K., Toda, T., Endo, T. CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of \u03b1-dystroglycan. J. Biol. Chem.,<\/em> 2018<\/strong>, 293<\/em>, 12186-12198.<\/li>\n
                5. Umezawa, K.<\/span>, Kamiya, M., Urano, Y. A reversible fluorescent probe for real-time live-cell imaging and quantification of endogenous hydropolysulfides. Angew. Chem. Int. Ed.<\/em>, 2018<\/strong>, 57<\/em>, 9346\u20139350.<\/li>\n
                6. Takahashi, K., Miura, Y.<\/u>, Ohsawa, I., Shirasawa, T., Takahashi, M. In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization. Sci. Rep.<\/em>, 2018<\/strong>, 8<\/em>, 15585.<\/li>\n<\/ol>\n

                  2017<\/strong><\/p>\n

                    \n
                  1. Kobayashi, M., Takeda, K., Narita, T., Nagai, K., Okita, N., Sudo, Y., Miura, Y.<\/span>, Tsumoto, H.<\/span>, Nakagawa, Y., Shimano, H., Higami, Y. Mitochondrial Intermediate Peptidase is a Novel Regulator of Sirtuin-3 Activation by Caloric Restriction. FEBS Letters<\/em>, 2017<\/strong>, 591<\/em>, 4067\u20134073.<\/li>\n
                  2. Tsumoto, H.<\/u>, Akimoto, Y., Endo, T., Miura, Y.<\/u> Quantitative analysis of O<\/i>-GlcNAcylation in combination with isobaric tag labeling and chemoenzymatic enrichment<\/span>. Bioorg. Med. Chem. Lett., <\/em>2017<\/strong>, 27<\/em>, 5022\u20135026.<\/li>\n
                  3. Mellini, P., Itoh, Y., Tsumoto, H<\/span>., Li, Y., Suzuki, M., Tokuda, N., Kakizawa, T., Miura, M<\/span>., Takeuchi, J., Lahtela-Kakkonene, M., Suzuki, T. Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, \u201cselectivity pocket\u201d and NAD+-binding site. Chem. Sci.<\/em>, 2017<\/strong>, 8<\/em>, 6400\u20136408.<\/li>\n
                  4. Nishikaze, T., Tsumoto, H<\/span>., Sekiya, S., Iwamoto, S., Miura, Y.<\/span>, Tanaka, K. Differentiation of Sialyl Linkage Isomers by One-Pot Sialic Acid Derivatization for Mass Spectrometry-Based Glycan Profiling. Anal. Chem<\/em>. 2017<\/strong>, 89<\/em>, 2353\u20132360.<\/li>\n
                  5. Akasaka-Manya, K., Kawamura, M., Tsumoto, H<\/u>., Saitoh, Y., Kitazume, S., Hatsuda, H., Miura, Y.<\/u>, Hisanaga, S., Murayama, S., Hashimoto, Y., Manya, H., Endo, T. Excess APP O<\/em>-glycosylation by GalNAc-T6 decreases A\u03b2 production. J. Biochem.<\/em> 2017<\/strong>, 161<\/em>, 99\u2013111.<\/li>\n
                  6. Murakami, M., Kameda, K., Tsumoto, H.<\/u>, Tsuda, T., Masuda, K., Utsunomiya, R., Mori, H., Miura, Y.<\/u>, Sayama, K. TLN-58, newly discovered hCAP18 processing form, found in the lesion vesicle of palmoplantar pustulosis in the skin. J. Invest. Dermatol.<\/em> 2017<\/strong>, 137<\/em>, 322\u2013331.<\/li>\n<\/ol>\n

                    2016<\/strong><\/p>\n

                      \n
                    1. Itoh, Y., Aihara, K., Mellini, P., Tojo, T., Ota, Y., Tsumoto, H.<\/u>, Solomon, V.R., Zhan, P., Suzuki, M., Ogasawara, D., Shigenaga, A., Inokuma, T., Nakagawa, H., Miyata, N., Mizukami, T., Otaka, A., Suzuki, T. Identification of SNAIL1 peptide-based irreversible lysine-specific demethylase 1-selective inactivators. J. Med. Chem.<\/em> 2016<\/strong>, 59<\/em>, 1531\u20131544.<\/li>\n<\/ol>\n

                      2015<\/strong><\/p>\n

                        \n
                      1. Miura, Y.<\/u>, Hashii, N., Tsumoto, H.<\/u>, Takakura, D., Ohta, Y., Abe, Y., Arai, Y., Kawasaki, N., Hirose, N., Endo, T., on behalf of SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians). Change in N<\/em>-glycosylation of plasma proteins in Japanese semisupercentenarians. PLos One<\/em>, 2015<\/strong>, 10<\/em>, e0142645.<\/li>\n
                      2. Tsumoto, H.<\/u>, Ogasawara, D., Hashii, N., Suzuki, T., Akimoto, Y., Endo, T., Miura, Y. <\/u>Enrichment of O<\/em>-GlcNAc-modified peptides using a novel thiol-alkyne and thiol-disulfide exchange. Bioorg. Med. Chem. Lett.<\/em> 2015<\/strong>, 25<\/em>, 2645\u20132649.<\/li>\n
                      3. Xin, X.; Akasaka-Manya, K.; Manya, H.; Furukawa, J.; Kuwahara, N.; Okada, K.; Tsumoto, H.<\/u>; Higashi, N.; Kato, R.; Shinohara, Y.; Irimura, T.; Endo, T. POMGNT1 Is Glycosylated by Mucin-Type O<\/em>-Glycans. Biol. Pharm. Bull.<\/em> 2015<\/strong>, 38<\/em>, 1389\u20131394.<\/li>\n
                      4. Kawakami, K., Fujita, Y., Kato, T., Mizutani, K., Kameyama,K., Tsumoto, H.<\/u>, Miura, Y.<\/u>, Deguchi, T., Ito, M.\u00a0 Integrin \u03b24 and vinculin contained in exosomes are potential markers for progression of prostate cancer associated with taxane-resistance. Int. J. Oncol.<\/em> 2015<\/strong>, 47<\/em>, 384\u2013390.<\/li>\n
                      5. Moriyama, T., Ito, A., Omote, S., Miura, Y.<\/u>, Tsumoto, H.<\/u>: Heat-Resistant Characteristics of Major Royal Jelly Protein 1 (MRJP1) Oligomer. PLos One<\/em>, 2015<\/strong>, 10<\/em>, e0119169.<\/li>\n
                      6. Miura, Y.<\/u>, Iwamoto, M.<\/u>, Tsumoto, H.<\/u>, Endo, T., Toda, T. Antioxidant effects of carnitine supplementation using fully automated two-dimensional chip gel electrophoresis. Electrophoresis Lett.<\/em> 2015<\/strong>, 59<\/em>, 109\u2013111.<\/li>\n
                      7. Kakizawa, T., Ota, Y., Itoh, Y., Tsumoto, H.<\/u>, Suzuki, T. Histone H3 peptide based LSD1-selective inhibitors. Bioorg. Med. Chem. Lett.<\/em> 2015<\/strong>, 25<\/em>, 1925\u20131928.<\/li>\n
                      8. Khan, M.N.A., Tsumoto, H.<\/u>, Itoh, Y., Ota, Y., Suzuki, M., Ogasawara, D., Nakagawa, H., Mizukami, T., Miyata N., Suzuki, T. Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1. Med. Chem. Commun.<\/em> 2015<\/strong>, 6<\/em>, 407\u2013412.<\/li>\n<\/ol>\n

                        2014<\/strong><\/p>\n

                          \n
                        1. Iwamoto, M.<\/u>, Miura, Y.<\/u>, Tsumoto, H.<\/u>, Tanaka, Y., Morisawa, H., Endo, T., Toda, T. Antioxidant effects of carnitine supplementation on 14-3-3 protein isoforms in the aged rat hippocampus detected using fully automated two-dimensional chip gel electrophoresis. Free Radic. Res.<\/em>, 2014<\/strong>, 48<\/em>, 1409\u20131416.<\/li>\n
                        2. Miura, Y.<\/u>, Sato, T., Sakurai, Y., Sakai, R., Hiraoka, W., Endo, T. Hyper O-GlcNAcylation inhibits HSP 70-induction caused by sodium arsenite in HeLa cells. Biol. Pharm. Bull.<\/em> 2014<\/strong>, 37<\/em>, 1308\u20131314.<\/li>\n<\/ol>\n

                          2013<\/strong><\/p>\n

                            \n
                          1. Miura, Y.<\/u>, & Endo, T. Challenge to successful aging -Proteomics on centenarians as a powerful tool for gerontology, Biomedical Gerotology<\/em>, 2013<\/strong>, 37<\/em>, 23\u201327.<\/li>\n
                          2. Ogasawara, D., Itoh, Y., Tsumoto, H.<\/u>, Kakizawa, T., Mino, K., Fukuhara, K., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T., Miyata, N., Suzuki, T. Lysine-Specific Demethylase 1-Selective Inactivators: Protein-Targeted Drug Delivery Mechanism. Angew. Chem. Int. Ed.<\/em> 2013<\/strong>, 52<\/em>, 8620\u20138624.<\/li>\n
                          3. Ozawa, K., Komatsubara, A.T., Nishimura, Y., Sawada, T., Kawafune, H., Tsumoto, H.<\/u>, Tsuji, Y., Zhao, J., Kyotani, Y., Tanaka, T., Takahashi, R., Yoshizumi, M. S-nitrosylation regulates mitochondrial quality control via activation of parkin. Sci. Rep.<\/em> 2013<\/strong>, 3<\/em>, 1\u201310.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

                            2025 Uchiyama, J., Shimizu, Y., Unoki, T., Kasamatsu, S., Ida, T., Ihara, H., Kim, Y. G., Hase, K., Miura, Y.,…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8"}],"version-history":[{"count":68,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":472,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages\/8\/revisions\/472"}],"wp:attachment":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}