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start=\"2\">\n<li><strong><em><u>O<\/u><\/em><\/strong><strong><u>-GlcNAc<\/u><\/strong><strong><u>\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u89e3\u6790<\/u><\/strong><\/li>\n<\/ol>\n<p><em>O<\/em>-GlcNAc\u5316\u306e\u5f79\u5272\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u4fee\u98fe\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u4fee\u98fe\u90e8\u4f4d\u3001\u5909\u52d5\u3082\u660e\u3089\u304b\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5fae\u91cf\u306a<em>O<\/em>-GlcNAc\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7db2\u7f85\u7684\u89e3\u6790\u306f\u5bb9\u6613\u3067\u306f\u306a\u304f\u3001\u9ad8\u611f\u5ea6\u306a\u5206\u6790\u6cd5\u306e\u958b\u767a\u304c\u671b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u8fd1\u5e74\u3067\u306f<em>O<\/em>-GlcNAc\u5316\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u89e3\u6790\u306b\u9175\u7d20\u53cd\u5fdc\u3068\u30af\u30ea\u30c3\u30af\u53cd\u5fdc\u304c\u5229\u7528\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u30a2\u30b8\u30c9\u57fa\u3092\u6709\u3059\u308b\u975e\u5929\u7136\u578bUDP-Gal\uff08UDP-GalNAz\uff09\u3068\u7cd6\u8ee2\u79fb\u9175\u7d20\u5909\u7570\u4f53Gal-T1(Y289L)\u3092\u7528\u3044\u3066 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loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-174\" src=\"https:\/\/tmig-proteome.org\/wp-content\/uploads\/2016\/11\/83824e7f19efc20c69f065704cefd33a.png\" alt=\"1-1_ O-GlcNAc_\u56f33\" width=\"850\" height=\"216\" \/>\u56f3\uff13<\/strong><\/p>\n<p>\u4eca\u5f8c\u3001\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u5206\u6790\u624b\u6cd5\u3092\u7528\u3044\u3066\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u52d5\u7269\u3084\u30d2\u30c8\u306e\u7d44\u7e54\u3092\u89e3\u6790\u3057\u3001\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b<em>O<\/em>-GlcNAc\u5316\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u95a2\u9023\u8ad6\u6587<\/li>\n<\/ul>\n<ol>\n<li>Tsumoto, H., Akimoto, Y., Endo, T., Miura, Y. <em> Med. Chem. Lett.,<\/em> <strong>2017<\/strong>, <em>27<\/em>, 5022-5026. doi: 10.1016\/j.bmcl.2017.10.005.<\/li>\n<li>Tsumoto, H., Ogasawara, D., Hashii, N., Suzuki, T., Akimoto, Y., Endo, T., Miura, Y. <em> Med. Chem. Lett.,<\/em> <strong>2015<\/strong>, <em>25<\/em>, 2645-2649. doi: 10.1016\/j.bmcl.2015.04.082.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306eO-GlcNAc\u5316 \u30bf\u30f3\u30d1\u30af\u8cea\u306eO-\u7d50\u5408\u578bN-\u30a2\u30bb\u30c1\u30eb\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\uff08O-GlcNAc\uff09\u5316\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30bb\u30ea\u30f3\uff08Ser\uff09\u3042\u308b\u3044\u306f\u30c8\u30ec\u30aa\u30cb\u30f3\uff08Thr\uff09\u6b8b\u57fa\u306e\u6c34\u9178\u57fa\u306b\u5bfe\u3057\u3066GlcNAc\u304c\u4e00\u3064\u3060\u3051\u4ed8\u52a0\u3055\u308c\u308b\u9175\u7d20\u7684\u7ffb&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-44","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages\/44","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44"}],"version-history":[{"count":11,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages\/44\/revisions"}],"predecessor-version":[{"id":242,"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=\/wp\/v2\/pages\/44\/revisions\/242"}],"wp:attachment":[{"href":"https:\/\/tmig-proteome.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}